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目的探讨亚急性坏死性淋巴结炎的病因、临床特征和实验室检查特点,以提高对亚急性坏死性淋巴结炎的认识。方法回顾性分析23例经病理确诊的临床病例。结果发病以学龄儿为主,平均年龄(8.8±2.3)岁,男女之比2∶3。临床主要表现为发热、淋巴结肿大、白细胞减少;抗EB病毒抗体阳性率高;21例给予肾上腺皮质激素治疗,效果显著。结论对于不明原因发热伴淋巴结肿大疼痛者,应尽早行淋巴结活检确诊,该病呈自限性,糖皮质激素治疗有效,但少数有复发,发展为系统性红斑狼疮可能,应长期随访。
Objective To investigate the etiology, clinical features and laboratory features of subacute necrotizing lymphadenitis in order to improve the understanding of subacute necrotizing lymphadenitis. Methods Retrospective analysis of 23 cases of pathologically confirmed clinical cases. Results The incidence of school-based children, the average age (8.8 ± 2.3) years old, male to female ratio of 2: 3. Clinical manifestations of fever, lymph nodes, leukopenia; anti-Epstein-Barr virus antibodies positive rate; 21 cases of adrenal cortex hormone therapy, the effect is significant. Conclusion For patients with unexplained fever and swollen lymph nodes, lymph node biopsy should be performed as soon as possible. The disease is self-limiting and glucocorticoid treatment is effective. However, a small number of relapsing and developing systemic lupus erythematosus may be followed for a long time.