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目的:比较密闭和开放不同条件下梭曼和乙基梭曼透皮吸收的特点。方法:采用动式离体皮渗透装置,接收液中梭曼或乙基梭曼的浓度采用微量电鳐乙酰胆碱酯酶抑制法测定。结果:梭曼或乙基梭曼皮肤染毒后,经过约15min的延搁期后经皮渗透量逐渐增加,至2~3h达高峰,之后逐渐下降。无论是开放或密闭条件染毒,乙基梭曼经皮渗透量均比梭曼多。毒剂皮肤染毒后9h,开放条件下,乙基梭曼经皮渗透量是梭曼的7.2倍;密闭条件下,乙基梭曼经皮渗透量是梭曼的4.1倍。结论:乙基梭曼透皮毒性比梭曼大的主要原因在于其经皮渗透能力较强。
OBJECTIVE: To compare the transdermal absorption characteristics of soman and ethyl soman under different conditions of airtightness and openness. Methods: Using the dynamic skin permeation device, the concentration of soman or ethyl soman in the receiving solution was determined by micro-electro- acetylcholinesterase inhibition. RESULTS: After soman or ethylsuman skin exposure, the amount of transdermal penetration gradually increased after a delay of about 15 minutes and peaked at 2 ~ 3 hours, then decreased gradually. Either in open or closed conditions exposure, ethyl Soman percutaneous penetration than Soman. Under the open condition, the permeation amount of ethyl soman was 7.2 times that of soman at 9h after exposure to the poison skin. In the closed condition, the percutaneous penetration of ethyl soman was 4.1 times that of soman. CONCLUSION: The main reason for the greater dermal toxicity of ethyl soman than soman is its high transdermal penetration.