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肾性继发性甲状旁腺功能亢进(SHPT)是慢性肾脏病最常见并发症之一,也是影响慢性肾脏病患者预后的重要因素,近年来成为研究热点。目前认为抗衰老蛋白α-Klotho与SHPT关系密切。现综述近年来α-Klotho对钙、磷代谢以及甲状旁腺激素的合成与分泌的影响,旨在进一步阐明α-Klotho蛋白在肾性SHPT发生、发展中的作用,进而为临床诊治提供科学依据。
Secondary renal hyperparathyroidism (SHPT) is one of the most common complication of chronic kidney disease, and also an important factor affecting the prognosis of patients with chronic kidney disease, which has become a research hot spot in recent years. At present, anti-aging protein α-Klotho and SHPT are closely related. The effects of α-Klotho on the synthesis and secretion of calcium and phosphorus metabolism and parathyroid hormone in recent years are reviewed to further elucidate the role of α-Klotho protein in the occurrence and development of renal SHPT and to provide a scientific basis for clinical diagnosis and treatment .