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目的研究长期给予大鼠一定剂量人参粉对大鼠肝肾功能有否影响。方法分别以4、6、8 g/(kgBW.d)3个剂量人参粉掺入基础饲料喂饲大鼠180 d,另设基础饲料对照组;于试验45、90、180 d动物空腹取血,测定血清Cr、ALT、BUN等指标,比较不同试验期各组动物肝肾功能相关生化指标的差异。结果不同时间段各剂量组与基础饲料组比较大鼠血清Cr、ALT、BUN等指标未见明显差异(测定值详见表1～表3,均P>0.05)。结论在一定剂量范围内长期喂养大鼠人参粉,对其肝肾功能未见不良影响。
Objective To investigate whether long-term administration of a certain dose of ginseng powder to rats has an effect on liver and kidney function in rats. Methods The rats were fed with 3 doses of ginseng powder (4,6,8 g/(kgBW.d)) for 180 days and fed with a basal diet control group. On the 45th, 90th, and 180th days of the experiment, the animals were treated with fasting blood. Serum Cr, ALT, BUN and other indicators were measured to compare the differences in liver and kidney function-related biochemical indexes between animals in different experimental periods. Results There were no significant differences in serum Cr, ALT, BUN and other indicators between the dose group and the basal diet group at different time periods (details are shown in Table 1 to Table 3, all P>0.05). Conclusion Long-term feeding of rat ginseng powder within a certain dose range has no adverse effects on liver and kidney function.