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目的探讨灌肠治疗葡萄糖-6-磷酸脱氢酶(G6PD)缺陷新生儿高胆红素血症的疗效。方法将82例G6PD缺陷新生儿高胆红素血症患儿随机分成二组,二组均采用综合治疗,治疗组42例用开塞露加生理盐水灌肠,每天1次,共5天,对照组无灌肠,观察记录二组新生儿每日TB值、光疗天数和胎粪排清时间。结果治疗组光疗天数和胎粪排清时间均比对照组缩短(P<0.05)。结论灌肠对G6PD缺陷新生儿高胆红素血症有治疗作用,能缩短光疗天数及胎粪排清时间。
Objective To investigate the efficacy of enema in the treatment of neonatal hyperbilirubinaemia with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Methods 82 cases of G6PD-deficient neonates with hyperbilirubinaemia were randomly divided into two groups. The two groups were treated with combination therapy. In the treatment group, 42 cases were treated with Kaixilinglu and saline, once a day for 5 days. Group without enema, observed and recorded two groups of newborns daily TB value, phototherapy days and meconium-clearing time. Results The days of phototherapy and the time of clearing of meconium in treatment group were shorter than those in control group (P <0.05). Conclusions The enema has a therapeutic effect on neonatal hyperbilirubinemia with G6PD deficiency, which can shorten the days of phototherapy and the time of clearing of meconium.