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对１９９３年１月至１９９６年１２月出生的７７４２例新生儿中先天性畸形发病情况及其影响因素进行回顾分析。结果显示：本组畸形发生率为１２．２７‰，先天性心脏病居首位，占４４．２％。男女发生率无明显差异（Ｐ＞０．２）；≥３５岁产妇新生儿畸形发生率明显高于＜３５岁者（Ｐ＜０．００１）；早产、过期产儿畸形发生率均显著高于足月产儿（Ｐ＜０．００１）；本组孕妇ＨＢｓＡｇ阳性率为９．３％，与畸形发生无明显关系（Ｐ＞０．２）。本组畸形儿死亡２０例，占同期围产儿死亡的３１．３％（２０／６４）。应加强优生宣教，减少高龄生产及多产；加强孕中期畸形筛查，以减少畸形儿的出生，降低围产儿死亡率
The incidence of congenital malformations in 7742 newborns born from January 1993 to December 1996 and its influential factors were retrospectively analyzed. The results showed that: the incidence of deformity in this group was 12.27 ‰, congenital heart disease ranks first, accounting for 44.2%. There was no significant difference in the incidence of males and females (P> 0.2). The incidence of neonatal malformations in women over 35 years old was significantly higher than that in children <35 years old (P <0.001) (P <0.001). The positive rate of HBsAg in pregnant women was 9.3%, which had no significant relationship with deformity (P> 0.05). Twenty children died of malformations, accounting for 31.3% (20/64) of perinatal deaths in the same period. Should strengthen eugenics missionary, to reduce the elderly and prolific production; strengthen the second trimester deformity screening to reduce the birth of deformed children, reduce perinatal mortality