论文部分内容阅读
目的观察氯沙坦与吲哒帕胺联合用药对原发性高血压患者血压、血钾、血糖、尿酸、血脂的影响。方法将符合诊断标准的150例老年高血压患者电脑随机分为3组,每组50例,进行用药前后自身对照试验,8周后检测各组血压、血钾、血糖、尿酸、血脂值。结果3组治疗后收缩压和舒张压均较前明显降低,联合治疗组降压幅度最大,氯沙坦组和联合治疗组治疗后尿酸值较治疗前降低,吲哒帕胺组治疗后血钾值较治疗前降低。结论氯沙坦与吲哒帕胺联合应用不仅具有协同降压作用,而且能降低尿酸,减轻吲哒帕胺引起的低钾血症。
Objective To observe the effects of losartan and indapamide on the blood pressure, serum potassium, blood glucose, uric acid and blood lipids in patients with essential hypertension. Methods A total of 150 elderly patients with hypertension were divided into three groups according to the diagnostic criteria. Each group included 50 patients. The control group was self-controlled before and after treatment. After 8 weeks, the blood pressure, serum potassium, blood glucose, uric acid and blood lipid were measured. Results After treatment, the systolic and diastolic blood pressures in the three groups were significantly lower than those in the previous groups. The combined treatment group had the largest decrease in blood pressure, while the uric acid levels in losartan group and combination group were lower than those before treatment. After treatment with indapamide group, Value lower than before treatment. Conclusion The combination of losartan and indapamide not only has synergistic antihypertensive effect, but also reduces uric acid and reduces indapamide-induced hypokalemia.