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目的探讨人工流产后继发性不孕妇女抗精子抗体(ASAb)、抗子宫内膜抗体(EMAb)和抗人绒毛膜促性腺激素抗体(HCGAb)监测的意义。方法选择人工流产后继发性不孕妇女156例;另选有正常生育能力的妇女80例做对照。应用酶联免疫吸附法分别测定血清ASAb、EMAb、HCGAb。结果人工流产后继发性不孕女性血清ASAb、EMAb和HCGAb阳性率均明显升高。正常组与之比较差异有统计学意义(P<0.05)。结论 ASAb、EMAb和HCGAb与人工流产后继发性不孕有一定关系,自身免疫抗体的异常可能是人工流产后继发性不孕的一个重要因素。
Objective To investigate the significance of anti-sperm antibody (ASAb), anti-endometrial antibody (EMAb) and anti-human chorionic gonadotropin antibody (HCGAb) in women with secondary infertility after induced abortion. Methods 156 cases of secondary infertility women after artificial abortion were selected; another 80 women with normal fertility were selected as controls. Serum ASAb, EMAb and HCGAb were measured by enzyme-linked immunosorbent assay. Results The positive rates of serum ASAb, EMAb and HCGAb were significantly higher in women with secondary infertility after induced abortion. The difference between the normal group was statistically significant (P <0.05). Conclusions ASAb, EMAb and HCGAb may be related to secondary infertility after induced abortion. The abnormality of autoimmune antibodies may be an important factor of secondary infertility after induced abortion.