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目的探讨妊高征患者子宫胎盘床、胎盘血管病变及其与妊娠结局的关系。方法应用免疫组化技术对２９例重度妊高征（妊高征组）和２９例正常妊娠妇女（对照组）的子宫胎盘床、胎盘血管壁ＩｇＡ、ＩｇＧ、ＩｇＭ和Ｃ３的表达进行检测。结果妊高征组胎盘绒毛和子宫胎盘床血管壁ＩｇＡ、ＩｇＧ、ＩｇＭ和Ｃ３的阳性表达率（胎盘绒毛：２０．１％，２４．１％，７２．４％和６５．５％；胎盘床：２０．０％，２０．０％，７０．０％和６０．０％）均分别显著高于对照组（Ｐ＜０．０５），而对照组均呈阴性表达。妊高征组胎盘免疫复合物和补体沉积处多可见血管内膜增厚、管腔狭窄、纤维素样坏死和急性动脉粥样化病变。妊高征合并宫内发育迟缓（ＩＵＧＲ）者免疫复合物和补体的阳性表达率（７６．２％）显著高于未合并ＩＵＧＲ者（５０％，Ｐ＜０．０５）。结论重度妊高征时，子宫、胎盘血管有免疫复合物和补体沉积，在妊高征的发生和发展中，免疫因素起着重要作用
Objective To investigate the relationship between uterine placenta bed, placental vascular disease and pregnancy outcome in patients with pregnancy induced hypertension. Methods Immunohistochemistry was used to detect the expression of IgA, IgG, IgM and C3 in the uteroplacental and placental wall of 29 patients with severe PIH and 29 normal pregnant women (control group). Results The positive rates of IgA, IgG, IgM and C3 in the placenta of placenta and placenta of PIH group (20.1%, 24.1%, 72.4% and 65.5% : 20.0%, 20.0%, 70.0% and 60.0%, respectively) were significantly higher than those in the control group (P <0.05), while those in the control group were all negative. PIH placental immune complexes and complement deposition more visible intimal thickening, stenosis, fibroids necrosis and acute atherosclerotic lesions. The positive rate of immune complex and complement in PIH with intrauterine growth retardation (IUGR) was significantly higher (76.2%) than those without IUGR (50%, P <0.05). Conclusions Severe PIH, the uterus, placental vascular immune complexes and complement deposition, in the occurrence and development of pregnancy-induced hypertension, immune factors play an important role