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目的 :探讨黄芪女贞子汤治疗消化道肿瘤作用机理。方法 :应用体外细胞培养的方法 ,观察黄芪女贞子汤对各种人体消化道肿瘤细胞的抑制作用 ,并分析癌细胞培养上清中的 Matrix Matalloproteinase- 7( MMP- 7,m atrilysin)的分泌状况。结果 :黄芪女贞子汤对胃、大肠消化道的 9种癌细胞有明显的抑制作用 ,而对 3种正常纤维细胞有增殖促进作用 ( P <0 .0 5 ) ;黄芪女贞子汤具有减少 m atrilysin的分泌作用 ( P <0 .0 5 )。结论 :黄芪女贞子汤可能通过减少 m atrilysin的分泌而起到对肿瘤细胞的抑制作用和抗转移作用。
Objective: To explore the mechanism of action of Huangqi Nuzhenzi Decoction in treating digestive tract tumors. METHODS: In vitro cell culture method was used to observe the inhibitory effects of Astragalus membranaceus decoction on various human digestive tract tumor cells, and the secretion of Matrix Matalloproteinase-7 (MMP- 7 , a matrilysin) in the culture supernatant of cancer cells was analyzed. situation. Results: Astragalus membranaceus decoction significantly inhibited 9 kinds of cancer cells in the digestive tract of the stomach and large intestine, but promoted the proliferation of 3 types of normal fibroblasts (P < 0.05). The secretion of m atrilysin was decreased (P < 0.05). Conclusion: Astragalus membranaceus soup may play an inhibitory and anti-metastasis effect on tumor cells by reducing the secretion of m atrilysin.