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目的观察补硒治疗自身免疫性甲状腺炎(AITD)的效果。方法选取博爱县人民医院2010年1月至2012年6月收治的100例采用补硒治疗的AITD患者,将其随机分为治疗组和对照组,每组50例,对治疗组进行补硒治疗,对照组采取常规治疗,比较两组患者治疗前后的促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)及游离甲状腺素(FT4)等指标的变化。结果两组治疗后3个月及6个月FT4、FT3和TSH比较差异均未见统计学意义(P>0.05);治疗组抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体均下降,对照组抗体水平明显提高,差异有统计学意义(P<0.05)。结论补硒治疗能够有效降低AITD患者甲状腺的抗体水平,值得临床推广和应用。
Objective To observe the effect of selenium supplementation on autoimmune thyroiditis (AITD). Methods 100 cases of AITD treated with selenium supplementation were selected from People’s Hospital of Bao’ai County from January 2010 to June 2012 and randomly divided into treatment group and control group, with 50 cases in each group. Selenium treatment . The control group was given routine treatment. The changes of thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) before and after treatment were compared between the two groups. Results There were no significant differences in FT4, FT3 and TSH between the two groups at 3 months and 6 months after treatment (P> 0.05). Anti-thyroglobulin antibody and anti-thyroid peroxidase antibody decreased The level of antibody was significantly increased, the difference was statistically significant (P <0.05). Conclusion Selenium treatment can effectively reduce the level of thyroid antibodies in patients with AITD, which is worthy of clinical promotion and application.