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染色体不稳定性被认为是恶性肿瘤细胞的特征性改变,而细胞有丝分裂异常可以引起染色体不稳定。中心体作为细胞的主要微管组织中心,在细胞周期中建立有丝分裂纺锤体,调节细胞有丝分裂,从而对维持染色体的稳定起着重要作用。因此肿瘤细胞基因不稳定可能与中心体异常密切相关。中心体异常是恶性肿瘤细胞的普遍特征。现就有关中心体异常在恶性肿瘤特别是膀胱移行细胞癌发生进展中的作用作一综述。
Chromosomal instability is thought to be a characteristic change in malignant cells, and cell mitosis can cause chromosomal instability. The centrosome, as the major microtubule center of cells, establishes a mitotic spindle in the cell cycle and regulates mitosis, which plays an important role in maintaining the stability of the chromosome. Therefore, tumor cell gene instability may be closely related with centrosome abnormalities. Centrosome abnormalities are a common feature of malignant cells. Now on the central body abnormalities in malignant tumors, especially the progress of bladder transitional cell carcinoma in the role of review.