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目的了解左氧氟沙星的不良反应(ADR)及原因,为临床合理用药提供参考。方法采用回顾性分析方法,对郑州市中心医院2007-11-2010-11上报的67例左氧氟沙星致ADR情况进行分类统计和分析。结果左氧氟沙星的ADR有过敏反应(53.73%)、中枢神经系统反应(8.96%)、心血管系统反应(13.43%)、消化系统反应(16.42%)、血液及免疫系统反应(13.43%)等。ADR发生率与患者年龄、剂型、用药剂量、频率、疗程、联合用药等有关。结论临床应重视左氧氟沙星的合理安全用药,以预防和减少ADR的发生。
Objective To understand the adverse reactions (ADRs) of levofloxacin and its causes, so as to provide a reference for clinical rational drug use. Methods Retrospective analysis was used to classify and analyze ADR of 67 levofloxacin cases reported by Zhengzhou Central Hospital from 2007-11-2010-11. Results ADR of levofloxacin was 53.73%, central nervous system reaction (8.96%), cardiovascular system response (13.43%), digestive system reaction (16.42%), blood and immune system response (13.43%) and so on. The incidence of ADR and patient age, dosage form, dosage, frequency, duration of treatment, combination therapy and so on. Conclusion Clinical should pay attention to the rational safety of levofloxacin to prevent and reduce the occurrence of ADR.