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目的:探讨颈部淋巴结转移及腺体外侵犯等甲状腺乳头状癌患者的临床病理学特征与BRAFn V600E基因突变丰度的关系。n 方法:回顾性分析2018年1月至2020年10月北京大学人民医院123例甲状腺乳头状癌患者的临床病理资料，术后行二代测序技术检测，分析BRAFn V600E基因突变丰度与肿瘤侵袭、颈部淋巴结转移及其他临床病理特征的关系。n 结果:淋巴结转移组和腺体外侵犯组的BRAFn V600E基因突变丰度高于对照组，各突变组的淋巴结转移率均高于无突变组，差异有统计学意义（均n P<0.05）；随着BRAFn V600E基因突变丰度的升高，腺外组织侵犯及邻近器官侵犯的发生率均升高，肿瘤侵犯程度与BRAFn V600E基因突变丰度呈正相关，差异均有统计学意义（n P<0.05）。n 结论:甲状腺乳头状癌患者的BRAFn V600E基因突变丰度与肿瘤侵袭和颈部淋巴结转移有关。n “,”Objective:To investigate the correlation between cervical lymph node metastasis,extra thyroidal extension and other clinicopathologic features and BRAFn V600E gene mutation abundance in papillary thyroid carcinoma.n Methods:The clinicopathologic data of 123 PTC patients admitted from Jan 2018 to Oct 2020 in Peking University People\'s Hospital were analyzed retrospectively. All the PTC cases were examined by next generation sequencing technology. BRAFn V600E gene mutation abundances were detected and analyzed with different clinicopathologic features, and differences between groups were compared.n Results:There were statistical differences compared to control group in BRAFn V600E gene mutation abundances in lymph node metastasized group and extra thyroidal extended group(all n P<0.05). BRAFn V600E gene mutation abundances were positively related with severity of extra thyroidal extension(n P<0.05).n Conclusion:BRAFn V600E gene mutation abundance was related with cervical lymph node metastasis and extra thyroidal extension in PTC patients.n