论文部分内容阅读
目的:评价益气生骨颗粒促进骨折愈合的生物力学作用机制。方法:将24只2月龄雄性SD大鼠随机分为模型组和用药组,每组12只。全部手术法制作双侧桡骨中段骨折模型。造模次日,模型组予颗粒剂辅料(9.6g·kg~(-1)·d~(-1)),用药组予益气生骨颗粒(12g·kg~(-1)·d~(-1)),分两次灌胃,连续6周。第43天处死,检测桡骨力学性能、几何尺寸和基本物理参数(干重、体积和密度)。结果:与模型组比,用药组造模桡骨的断端截面惯性矩明显增大(P<0.05),承受最大载荷增高达(12.601±7.056)N,模型组为(7.974±5.463)N;相应的桡骨几何结构参数(如长度、折端处直径及横截面积)以及整个桡骨和骨痂的干重与体积均明显变大(P<0.01或P<0.05)。骨痴中无机质与有机质量均见明显升高(均P<0.01)。结论:益气生骨颗粒促进骨折愈合疗效确切,其机制为:通过优化整个造模桡骨宏观几何机构及增加其材料构成成分,增强其生物力学性能。
OBJECTIVE: To evaluate the biomechanical mechanism of Yiqi Shenggu granules in promoting fracture healing. Methods: Twenty-four male 2-month-old male Sprague-Dawley rats were randomly divided into model group and treatment group, with 12 rats in each group. All surgical methods to make bilateral mid radius fracture model. On the next day of modeling, the model group was treated with granule excipients (9.6g · kg -1 · d -1) (-1)), gavage twice in a row for 6 weeks. On the 43rd day, the radial mechanical properties, geometrical dimensions and basic physical parameters (dry weight, volume and density) were measured. Results: Compared with the model group, the moment of inertia of the radius end of the model group was significantly increased (P <0.05), the maximum load was increased to (12.601 ± 7.056) N and the model group was (7.974 ± 5.463) N; (Such as length, diameter and cross-sectional area of the fracture tip) and the dry weight and volume of the radial and callus were significantly increased (P <0.01 or P <0.05). The content of inorganic matter and organic matter in Bonechia showed a significant increase (all P <0.01). Conclusion: Yiqi Shengjuguli can promote the healing of fractures exactly. Its mechanism is to enhance its biomechanical properties by optimizing the macroscopic geometric structure of the entire radial artery and increasing its material composition.