论文部分内容阅读
N-三甲基壳聚糖(TMC)是壳聚糖的一种季胺盐衍生物,与壳聚糖具有相似的生物学性质,但TMC在中性及弱碱性条件下具有很好的溶解性。TMC作为载药体系其毒性较低、无抗原性且运载药物和基因的效率较高。离子交联法制备纳米粒操作简单,可避免因使用有机溶剂和超声等造成污染与破坏。本文综述TMC为载体的纳米粒研究进展。
N-trimethyl chitosan (TMC) is a quaternary ammonium salt derivative of chitosan with similar biological properties to chitosan, but TMC has good Solubility. TMC as a drug-loading system is less toxic, non-antigenic and carries more drug and gene efficiency. The preparation of nanoparticles by ion-crosslinking method is simple and can avoid the pollution and destruction caused by the use of organic solvents and ultrasound. This review summarizes the research progress of TMC-loaded nanoparticles.