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目的:探讨左氧氟沙星联合阿奇霉素治疗老年难治性呼吸道感染的临床效果,进一步指导临床治疗。方法:选择我院在2010年1月至2012年12月之间收治的老年难治性呼吸道感染患者80例作为本次研究对象,按照随机分组原则划分为观察组与对照组各40例,观察组患者采用左氧氟沙星联合阿奇霉素进行治疗,对照组患者采用左氧氟沙星进行治疗,对两组治疗效果进行观察及对比分析。结果:观察组患者的治疗有效率为92.5%,对照组治疗有效率为70.0%,两组治疗有效率对比差异显著,具有统计学意义P<0.05;且观察组不良反应发生率并没有显著提高,与对照组对比差异不显著,无统计学意义P>0.05。结论:采用左氧氟沙星联合阿奇霉素治疗老年难治性呼吸道感染,具有显著的临床效果,较单纯采用左氧氟沙星更为有效,且并不会导致不良反应增多,安全可靠,值得应用推广。
Objective: To investigate the clinical effect of levofloxacin combined with azithromycin in the treatment of elderly refractory respiratory tract infection and further guide the clinical treatment. Methods: 80 cases of elderly patients with refractory respiratory tract infection admitted to our hospital from January 2010 to December 2012 were selected as the study object. According to the principle of randomization, 40 cases were divided into observation group and control group. Patients in the group were treated with levofloxacin combined with azithromycin. Patients in the control group were treated with levofloxacin. The therapeutic effect was observed and compared between the two groups. Results: The effective rate of treatment was 92.5% in observation group and 70.0% in control group, with significant difference between the two groups (P <0.05), and the incidence of adverse reactions in observation group did not significantly increase , Compared with the control group, the difference was not significant, no statistical significance P> 0.05. Conclusion: Levofloxacin combined with azithromycin in elderly patients with refractory respiratory tract infection has a significant clinical effect, compared with the simple use of levofloxacin is more effective, and will not lead to increased adverse reactions, safe and reliable, it is worth to promote the application.