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目的探讨健脾滋肾法治疗系统性红斑狼疮(SLE)的疗效及对患者生活质量的改善作用。方法将50例SLE患者随机分为治疗组25例和对照组25例,对照组给予泼尼松片联合硫酸羟氯喹治疗,治疗组在此基础上,加用中药健脾滋肾汤。比较2组治疗前后的临床疗效,系统性红斑狼疮活动性标准(SLEDAI)积分变化,生活质量积分变化,抑郁(SDS)、焦虑(SAS)量表积分变化,中医症状积分变化,实验室指标变化。结果治疗组临床缓解4例,显效10例,有效8例,无效3例,总有效率为88.0%;对照组临床缓解2例,显效6例,有效10例,无效7例,总有效率为72.0%。经Ridit分析,U=2.771,P<0.05,说明治疗组疗效优于对照组。2组间治疗前后SLEDAI积分差值无显著性差异(P>0.05);治疗组治疗前后生活质量各维度积分和SAS、SDS积分差值与对照组比较均有统计学意义(P<0.01);治疗组治疗前后各项中医症状积分差值与对照组比较均有统计学意义(P<0.05);治疗组治疗前后实验室指标免疫球蛋白G(Ig G)、免疫球蛋白M(Ig M)、补体C4(C4)、超敏C反应蛋白(CRP)、白细胞(WBC)、红细胞(RBC)与对照组比较均有统计学意义(P<0.05)。结论健脾滋肾法治疗SLE取得了较好的临床疗效,对疾病活动度,生活质量积分、中医症状积分及抑郁焦虑量表积分等方面具有显著的改善作用,且安全性高,适合在临床推广使用。
Objective To investigate the therapeutic effect of spleen and kidney therapy on patients with systemic lupus erythematosus (SLE) and its effect on the quality of life of patients. Methods Fifty patients with SLE were randomly divided into treatment group (n = 25) and control group (n = 25). The control group was given prednisone tablets combined with hydroxychloroquine sulfate. On the basis of this, the treatment group was given Jianpi Zishen Decoction. The clinical efficacy, SLEDAI score changes, quality of life integral changes, depression (SDS), anxiety (SAS) score integral changes, TCM symptom score changes, laboratory changes in the indicators of the two groups were compared before and after treatment. . Results In the treatment group, 4 cases were clinically relieved, 10 cases were markedly effective, 8 cases were effective and 3 cases were ineffective. The total effective rate was 88.0%. In the control group, 2 cases were clinically relieved, 6 cases markedly effective, 10 effective and 7 ineffective. The total effective rate was 72.0%. Ridit analysis, U = 2.771, P <0.05, indicating that the treatment group than the control group. There were no significant differences in SLEDAI scores between the two groups before and after treatment (P> 0.05). The scores of quality of life and SAS, SDS scores before and after treatment in the treatment group were significantly different from those in the control group (P <0.01). Before and after treatment, the scores of TCM symptom scores in the treatment group were significantly different from those in the control group (P <0.05); before and after treatment in the treatment group, the indexes of immunoglobulin G (Ig G), immunoglobulin M (Ig M) , C4 (C4), CRP, WBC and RBC in the control group were significantly higher than those in the control group (P <0.05). Conclusion The treatment of SLE by Jianpi Zizhen method has a good clinical curative effect, which has significant improvement on disease activity, quality of life integrals, TCM symptom scores and depression and anxiety scale scores, and is safe and suitable for clinical application Promote use.