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目的:研究辛卡利特(sincalide)的抗吗啡作用及其作用机制,方法:采用了同步描记大鼠离体空肠电生理与机械活动的方法。结果:乙酰胆碱(ACh)可使大鼠离体空肠峰波振幅增大、数目增多,其收缩幅度随之增大,两者呈正相关,相反地,吗啡能抑制ACh的加强作用,呈负相关,辛卡利特能对抗吗啡的作用,即峰波振幅、数目再次增加,收缩幅度也随之增加。在此基础上,CCK-A受体拮抗剂地伐西匹能翻转辛卡利特的抗吗啡作用,结论:辛卡利特对抗吗啡抑制ACh加强空肠活动的作用,推测该作用是通过CCK-A受体实现的。
OBJECTIVE: To study the anti-morphine effect of sincalide and its mechanism of action. Methods: The synchronous electrophysiological and mechanical activities of rat jejunum were studied. RESULTS: Acetylcholine (ACh) increased the amplitude and amplitude of peak wave in isolated jejunum of rats, and the amplitude of contractility increased with the increase of ACh. On the contrary, morphine could inhibit the strengthening effect of ACh and was negatively correlated, Sinocalytic can counteract the effect of morphine, the peak wave amplitude, the number increases again, the magnitude of contraction also increases. On this basis, the CCK-A receptor antagonist venacetin could reverse the anti-morphine effect of simmelitat.CONCLUSIONS: The effect of simmelitat against morphine inhibition of ACh to enhance jejunal activity is speculated that this effect is mediated by CCK- A receptor.