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目的 比较成人接种不同种类、不同免疫程序、不同剂量狂犬病疫苗的免疫效果。方法 应用ELISA间接法对 1991～ 2 0 0 1年间在我站门诊注射狂犬端病疫苗的 2 172例成人进行抗体检测。结果 常规 5针法狂犬病疫苗的抗体阳性率为 70 0 8% ,浓缩狂犬病疫苗的阳性率为 83 0 5 % ,人用纯化狂犬病疫苗的阳性率为 97 0 6%。经统计学处理有非常显著性 (P <0 0 0 1)。浓缩狂犬病疫苗 7针法阳性率为 96 19% ,与人用纯化狂犬病疫苗常规 5针法比较 ,差异无显著性。结论 提示成人注射人用纯化狂犬病疫苗效果优于浓缩狂犬病疫苗 ,但抗体阳性率仍未能达到10 0 % ,对结果阴性者应及时补种疫苗。
Objective To compare the immunization effects of adult rabies vaccines of different kinds, different immunization programs and different doses of rabies vaccine. Methods A total of 2 172 adults who were infected with rabies vaccine during the period from 1991 to 2001 in our hospital were detected by ELISA indirect method. Results The positive rate of routine 5-pin rabies vaccine was 70 0 8%, that of concentrated rabies vaccine was 83 0 5%, and that of human rabies vaccine was 97 0 6%. Statistically significant (P <0.01). The positive rate of concentrated rabies vaccine on 7-acupuncture was 96.19%, which was not significantly different from that of routine 5-pin method on purified rabies vaccine. Conclusions The results suggest that the effect of rabies vaccine against rabies vaccine against adult rabbits is better than that of rabies vaccine, but the positive rate of antibody still fails to reach 100%. In the case of negative rabies vaccine, the vaccine should be timely vaccinated.