半胱氨酰白三烯是体内２０－碳不饱和脂肪酸经５－脂氧化酶途径代谢产生的生物活性物质，它们在体内进一步由肝脏代谢、失活和肝胆排泄，而肾脏也参与小部分的代谢过程。当肝脏发生病变时（出现阻塞性黄疸、肝内淤胆以及肝肾综合征等），由于肝脏代谢功能减弱，它们可代偿地转向肾脏代谢，表现为尿中检测量的增多。这可能是肝肾综合征的发生机制之一。 Cysteinyl leukotrienes are biologically active substances produced by the metabolism of 20-carbon unsaturated fatty acids in the body by the 5-lipoxygenase pathway, which are further metabolized, inactivated and hepatobiliary excreted by the liver in vivo, while the kidneys also participate in a small part of Metabolic process. When the liver lesions (obstructive jaundice, cholestasis of the liver and hepatorenal syndrome, etc.), due to the diminished metabolism of the liver, they can turn to the kidney metabolism in compensatory manner, showing increased detection of urine. This may be one of the mechanisms of hepatorenal syndrome.