AIM:To investigate the feasibility of compression anastomosis clip(CAC)for gastrointestinal anastomosis proximal to the ileocecal junction.METHODS:Sixty-six patients undergoing gastrointe-stinal anastomosis proximal to the ileocecal junction were randomized into two groups according to the anastomotic method,CAC or stapler.RESULTS:The postoperative recovery of patients in CAC and stapled anastomosis groups was similar.No postoperative complication related to the anastomotic method was found in either group.Both upper gastrointestinal contrast radiography at the early postoperative course and endoscopic examination after a 6-mo follow-up showed a better healing at the compression anastomosis.CONCLUSION:CAC can be used not only in colonic surgery but also in gastrointestinal anastomosis.Our result strongly suggests that CAC anastomosis is safe in various complication circumstances.However,it should be further confirmed with a larger patient sample.