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在云锡矿粉等诱发金仓鼠实验性肺腺癌的基础上，采用图像分析仪对诱癌过程中正常支气管粘膜上皮、增生支气管粘膜上皮、癌前病变和肺癌（Ⅰ～Ⅳ组）的细胞进行ＤＮＡ含量测定结果发现，从Ⅰ～Ⅳ组２Ｃ（ｃｏｍｐｏｎｅｎｔｓ）细胞百分比均值不断减少，３Ｃ～４Ｃ，５Ｃ细胞则不断增加在Ⅰ，Ⅱ组均未发现大于５Ｃ细胞；Ⅲ组仅出现少量大于５Ｃ细胞（４．００％）；Ⅳ组大于５Ｃ细胞明显升高（１０７５％），且Ⅲ，Ⅳ组间存在极为显著性差异（Ｐ＜００１）ＤＮＡ直方图，Ⅰ组显示主峰在２Ｃ处正态分布；Ⅱ，Ⅲ组直方图主峰开始降低，位置不固定，有第二峰形成，直方图加宽；Ⅳ组主峰更低或无明显主峰，有多峰形成，直方图明显加宽达２８Ｃ，而且呈不规则直方图形
Based on the experimental lung adenocarcinoma induced by gold tin powder in the tin-bearing tin mine, image analyzer was used to detect the normal bronchial mucosal epithelium, hyperplastic bronchial epithelium, precancerous lesions, and cells of lung cancer (groups I-IV) during carcinogenesis. Assay of DNA content revealed that the percentage of 2C (components) cells in groups I to IV decreased continuously, and that of 3C to 4C and 5C cells continued to increase. No more than 5C cells were found in groups I and II; only small amounts appeared in group III. Greater than 5C cells (4.00%); IV group greater than 5C cells increased significantly (10 75%), and there was a significant difference between III, IV groups (P <0 01) DNA histogram, group I The main peaks show a normal distribution at 2C; the main peaks of groups II and III begin to decrease, the positions are not fixed, and the second peaks form, and the histogram widens; the IV main peaks are lower or have no obvious main peaks, and multiple peaks form. The figure is obviously widened to 28C, and it is irregularly shaped.