论文部分内容阅读
褪黑素在神经-内分泌-免疫调节网络中起着极其重要的作用。通过直接作用于靶器官上的褪黑素受体或间接作用于吗啡受体而发挥其免疫调节作用。在生理状态下维系并激活免疫细胞功能和细胞因子的产生使免疫应答最优化,并通过缓慢的昼夜节律重置而维持免疫自稳状态。在一些免疫相关性疾病(如肿瘤、胰岛素依赖性糖尿病、获得住免疫缺陷综合征、类风湿性关节炎、阿尔茨海默病、以及丛集性头痛症等)的发生、发展和治疗的各方面均与褪黑素有着密切的关系,本文就此作了较详尽的阐述,旨在对褪黑素的免疫调节机制作进一步的探讨,以期合理开发应用褪黑素,为免疫相关性疾病的治疗开拓新的领域。
Melatonin plays an extremely important role in the neuro-endocrine-immune regulatory network. Its immunomodulatory effect is exerted by acting directly on the target organ of the melatonin receptor or indirectly on the morphine receptor. Maintaining and activating immune cell function and the production of cytokines in the physiological state optimizes the immune response and maintains an immuno-stable state through slow circadian rhythm reset. In various aspects of the development, treatment and treatment of some immune-related diseases (such as cancer, insulin-dependent diabetes mellitus, acquired immune deficiency syndrome, rheumatoid arthritis, Alzheimer’s disease, and cluster headache) Are closely related with melatonin, this article made a more elaborate elaboration on the mechanism of melatonin immunomodulatory further exploration, with a view to the rational development and application of melatonin for the treatment of immune-related diseases to explore new area.