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美《医学论坛》第22卷第25期(1981年)报道旧金山消息:据俄勒冈大学研究人员的报告,他们在初步试验中已能安全地突破人的血脑屏障;他们所采用的渗透性可逆步骤能够增加输送至脑瘤的药量。纽威尔特(Edward Neuwelt)医生及其同事应用高渗甘露醇在动脉内注射,证明可使血脑屏障改变,维持这30分钟。至今,他们在11例晚期原发性脑瘤病人中已通过血脑屏障50次。这些病人是以输注氨甲喋呤治疗的。神经外科副教授兼生化副教授纽威尔特在美国神经
Report from the U.S. Medical Tribune Vol. 22, No. 25 (1981) SAN FRANCISCO: According to researchers at the University of Oregon, they have been able to safely penetrate the human blood-brain barrier in preliminary trials; their permeability reversal The procedure can increase the dose delivered to the brain tumor. Dr. Edward Neuwelt and colleagues injected intra-arteries with hypertonic mannitol, demonstrating a change in the blood-brain barrier that lasts for 30 minutes. To date, they have passed the BBB 50 times in 11 patients with advanced primary brain tumors. These patients are treated with methotrexate infusion. New Wilton, associate professor of neurosurgery and associate professor of biochemistry in the United States