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目的探讨除甲胎蛋白(AFP)外,其它肿瘤标志物在老年原发性肝癌外周血中的改变及临床意义。方法选取2013年1月至2016年1月间青海省第五人民医院收治的45例原发性肝癌患者为观察组,另选取同期体检的40例老年人为对照组。检测两组外周血中肿瘤标志物水平,并分析其临床意义。结果观察组患者外周血组织中多肽特异性抗原(TPS)和癌胚抗原(CEA)水平,均显著高于对照组,差异均有统计学意义(均P<0.05)。观察组患者外周血TPS(r=0.871,P<0.01)及CEA(r=0.955,P<0.01)与AFP均呈显著正相关关系。而TPS诊断原发性肝癌的敏感性为86.7%,特异性为82.5%,曲线下面积为0.87,优于CEA。结论 TPS与CEA在老年原发性肝癌患者外周血中表达升高,具有辅助诊断价值。
Objective To investigate the changes and clinical significance of other tumor markers in the peripheral blood of elderly patients with primary liver cancer except AFP. Methods Forty-five patients with primary liver cancer admitted to the Fifth People’s Hospital of Qinghai Province from January 2013 to January 2016 were selected as the observation group. Forty elderly patients were selected as the control group. Tumor markers in both groups were detected and their clinical significance was analyzed. Results The levels of TPS and CEA in the peripheral blood of the observation group were significantly higher than those of the control group (all P <0.05). There was a significant positive correlation between AFP and TPS (r = 0.871, P <0.01) and CEA (r = 0.955, P <0.01) in the observation group. The TPS diagnosis of primary liver cancer sensitivity was 86.7%, specificity was 82.5%, the area under the curve was 0.87, better than CEA. Conclusion The expression of TPS and CEA in the peripheral blood of elderly patients with primary liver cancer is elevated, which has the value of auxiliary diagnosis.