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急性早幼粒细胞白血病(APL)曾被认为是最迅速的致命白血病,特点为临床表现凶险,早期死亡率高,治愈率低。药物全反式维甲酸及亚砷酸的应用,使APL的治疗取得了很大成功,其完全缓解率可达90%。然而APL的复发率仍然较高,约15%-30%。降低复发率和提高长期生存已成为研究重点,如何选择合理的缓解后治疗策略至关重要。缓解后治疗一般包括巩固治疗和维持治疗,而最佳治疗方案的确定仍然有待商榷。因此,本文就APL缓解后巩固治疗回顾相关文献进行整合分析,综述APL巩固治疗的研究进展。
Acute promyelocytic leukemia (APL) has been considered the most rapid fatal leukemia, characterized by dangerous clinical manifestations, high early mortality, the cure rate is low. The use of all-trans retinoic acid and arsenious acid drugs, the success of the APL treatment has been achieved, the complete remission rate of up to 90%. However, the recurrence rate of APL is still high, about 15% -30%. Reducing the recurrence rate and improving the long-term survival have become the research focuses, and how to choose a reasonable post-treatment strategy is very important. Post-remission treatment generally includes consolidation and maintenance, and the determination of the best treatment remains open to question. Therefore, this article summarizes the relevant literature on APL mitigation consolidation therapy review summarizes the APL consolidation therapy research progress.