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目的:观察评价特利加压素、内镜套扎和联合上述两种方法治疗食管静脉曲张破裂出血的疗效.方法:56例患者分为三组,其中特利加压素组19例,内镜套扎组20例,联合治疗组17例.结果:72小时止血率在三组分别为68.4%,80%和94.l%;一周内再出血率为30.8%,12.5%和6.3%;急诊手术率为26.3%,21.1% 和5.9%.联合治疗组的72小时止血率明显高于其他两组(P<0.05),一周再出血率和急诊手术率低于其他两组(P<0.05) .特利加压素组和内镜套扎组的72小时止血率则没有差别(P>0.05 ).结论:食管静脉曲张破裂出血时联合应用特利加压素和内镜套扎治疗可以提高止血率、降低近期再出血率和急诊外科手术率.
Objective: To evaluate the efficacy of terlipressin, endoscopic ligation and the combination of the above two methods in the treatment of esophageal variceal bleeding.Methods: Fifty-six patients were divided into three groups, including 19 patients in terlipressin group, 20 cases in the mirror ligation group and 17 cases in the combined treatment group.Results: The rate of hemostasis in 72 hours was 68.4%, 80% and 94.1% respectively in the three groups, and the recurrence rates were 30.8%, 12.5% and 6.3% in one week respectively. The emergency operation rate was 26.3%, 21.1% and 5.9%, respectively, and the rate of hemostasis 72 hours in combined treatment group was significantly higher than that in the other two groups (P <0.05) ) .There was no difference in the rate of hemostasis 72 hours between the terlipressin group and the endoscopic ligation group (P> 0.05) .Conclusion: The combined application of terlipressin and endoscopic ligation in the treatment of esophageal variceal hemorrhage can Improve hemostatic rate, reduce the rate of recent rebleeding and emergency surgery rate.