本文首次报道应用怀孕母鼠进行实验,复制大骨节病模型。同胎母鼠经过交配后分笼饲养;对照组饲实验室常规粮、蒸馏水;非病区组饲辽宁省北镇粮、100ppm 北镇 FA 水;病区组饲甘肃省天水粮、100ppm 天水 FA 水。子鼠生后6周检测,结果是:1、病区组仔鼠生长速度缓慢,体重明显小于非病区组和对照组;2、与非病区组比较,病区组子鼠血液 SOD 活力显著升高,GSH-Rx 活力显著降低,LPO 量也显著减少。心肌、肝、和腓肠肌三种组织相比较,心肌反应性较安定,酶活力改变不大;肝组织反应强烈,SOD 活力显著降低,GSH-Px 活力显著升高,与血液的酶活力变化相反;腓肠肌 SOD 活力没有变化,GSH-Px 活力显著降低,LPO 量也显著减少,改变与血液相似,可能属于病理性反应;3、病区组子鼠的胫骨近端见有骺板变薄、酸性粘多糖明显减少、骨小梁稀少、深层肥大细胞胞质少、核缺失等病理改变。对大骨节病的有机质病因学与过氧化损伤的关系做了粗浅讨论。 This article for the first time reported the use of pregnant mothers to experiment, copy Kashin-Beck disease model. The same group of female rats were housed in cage after mating; the control group fed conventional food and distilled water; the non-diseased group was fed with 100ppm North Town FA water; the ward was fed Gansu Tianshui Food, 100ppm Tianshui FA water. 6 weeks after birth, the offspring test results showed that: 1, the ward rats in the ward slow growth rate, body weight was significantly smaller than the non-ward group and the control group; 2, compared with non-ward group, Significantly increased, GSH-Rx significantly reduced vitality, LPO volume was also significantly reduced. Myocardial reactivity was stable and enzyme activity was not changed much in myocardial, liver and gastrocnemius tissues. The liver tissue reacted strongly, the activity of SOD decreased significantly, the activity of GSH-Px increased significantly, which was opposite to that of blood. Gastrocnemius muscle SOD activity did not change, GSH-Px significantly reduced vitality, LPO volume was also significantly reduced, the change is similar to the blood may be pathological reactions; 3, the ward of the ward see proximal tibia thinning, acid sticky Polysaccharides significantly reduced trabecular thinning, less mast cell cytoplasm, nuclear loss and other pathological changes. Kashin-Beck disease organic matter etiology and the relationship between peroxide damage done a superficial discussion.