本文报道Fc-23、Rpm-5、Rrr-20和Fp-15等4种中药提取物对DNA损伤剂盐酸氮芥诱发的人体白细胞非程序DNA合成(UDS)的保护作用。结果显示,8.3—83.3mg/ml Fc-23、3.3—16.0 mg/ml Rpm-5,3.3—10.0 mg/ml Rrr-20和16.7—83.3 mg/ml Fp-15均能明显的降低盐酸氮芥诱发的UDS值,表明这4种中药提取物有抗诱发DNA损伤的作用。4种中药提取物的抗DNA损伤成分是耐热性的,中药提取物本身均无诱发UDS作用。本工作提示了应用传统中药成分用于抗诱发遗传毒害有可喜的前景。 This article reported the protective effect of four kinds of traditional Chinese medicine extracts such as Fc-23, Rpm-5, Rrr-20 and Fp-15 on non-program DNA synthesis (UDS) induced by DNA damage agent nitrogen mustard. The results showed that 8.3-83.3 mg/ml Fc-23, 3.3-16.0 mg/ml Rpm-5, 3.3-10.0 mg/ml Rrr-20 and 16.7-83.3 mg/ml Fp-15 all significantly reduced the hydrochloride mustard. The induced UDS values ​​indicated that the four Chinese herbal extracts had anti-induced DNA damage. The anti-DNA damage components of the four Chinese herbal extracts were heat-resistant, and the Chinese herbal extracts themselves did not induce UDS. This work suggests a promising prospect for using traditional Chinese medicine ingredients for anti-inducing genetic toxicity.