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目的探讨胎膜早破孕妇羊水中白细胞介素-8(IL-8)水平与绒毛膜羊膜炎的关系。方法用酶联免疫法(ELISA法)测定62例胎膜早破孕妇和46例正常足月妊娠未临产孕妇羊水中IL-8浓度;病理检查两组分娩后的胎膜组织,确定有无绒毛膜羊膜炎。结果胎膜早破组羊水中IL-8浓度高于对照组(P<0.05),破膜时间超过24h其羊水中IL-8水平明显高于破膜时间小于12h内的患者,绒毛膜羊膜炎组羊水中IL-8浓度高于对照组(P<0.05)。结论胎膜早破及绒毛膜羊膜炎孕妇羊水中IL-8水平显著升高,可作为绒毛膜羊膜炎的早期诊断指标。
Objective To investigate the relationship between the level of interleukin-8 (IL-8) in amniotic fluid and chorioamnionitis in premature rupture of membranes. Methods The levels of IL-8 in amniotic fluid of 62 cases of premature rupture of membrane and 46 cases of normal term pregnancy were determined by enzyme-linked immunosorbent assay (ELISA). The pathological examination of fetal membranes in the two groups Amniotic membrane inflammation. Results The concentration of IL-8 in amniotic fluid in premature rupture of membranes was significantly higher than that in control group (P <0.05). The level of IL-8 in amniotic fluid was significantly higher than that in control group after rupture of membranes for more than 24 hours, chorioamnionitis The concentration of IL-8 in amniotic fluid was higher than that in control group (P <0.05). Conclusion The level of IL-8 in amniotic fluid of premature rupture of membranes and chorioamnionitis is significantly increased, which can be used as an early diagnostic indicator of chorioamnionitis.