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目的：观察失碳长春碱（ＮＶＢ）加顺铂（ＤＤＰ）与长春花碱酰胺（ＶＤＳ）加顺铂两种联合化疗方案治疗晚期非小细胞肺癌（ＮＳＣＬＣ）的疗效及毒性反应。方法：对收治的７６例ＮＳＣＬＣ患者随机分成两组，Ａ组（ｎ＝３８）：ＮＶＢ ２５ ｍｇ／ｍ～２＋生理盐水８０～１００ ｍｌ于第１天，第８天或第５天静注，ＤＤＰ ８０～１００ ｍｇ／ｍ～２＋２．５％氯化钠２５０～５００ ｍｌ于第１天或分５ ｄ静点。Ｂ组（ｎ＝３８）：ＶＤＳ ３ ｍｇ／ｍ～２＋生理盐水６０～８０ ｍｌ于第１天、第８天或第５天静注，ＤＤＰ用法同Ａ组。两组均为２１～２８ｄ重复疗程。结果：完成２个疗程以上化疗者６６例。总有效率（ＣＲ＋ＰＲ）３９．４％（２６／６６），其中Ａ组３２例，有效１５例。Ｂ组３４例，有效１１例，经Ｘ～２检验两组无统计学差异。毒性以骨髓抑制白细胞减少最常见，Ａ组Ⅲ～Ⅳ级１９例，均使用粒细胞－集落刺激因子（Ｇ－ＧＳＦ）治疗。Ｂ组Ⅲ～Ⅳ级９例，有５例使用Ｇ－ＣＳＦ治疗。少数出现贫血及血小板减少。消化道反应多为Ｉ～Ⅱ级的恶心呕吐，腹胀便秘。两组各有１例出现麻痹性肠梗阻。Ａ组有２例出现严重的静脉炎。Ａ组中位缓解期及中位生存期分别为６个月及８个月，Ｂ组则分别为４?
OBJECTIVE: To observe the curative effect and toxicity of NVC combined with cisplatin (DDP) and vinblastine (VDS) plus cisplatin in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: A total of 76 NSCLC patients were randomly divided into two groups. Group A (n = 38): NVB 25 mg / m 2 + normal saline 80-100 ml were intravenously injected on day 1, day 8 or day 5, DDP 80 ~ 100 mg / m ~ 2 + 2.5% sodium chloride 250 ~ 500 ml on the first day or sub-5d static point. Group B (n = 38): VDS 3 mg / m ~ 2 + saline 60 ~ 80 ml were intravenously administered on day 1, day 8 or day 5, and DDP was used as group A. Both groups were 21 ~ 28d repeat treatment. Results: 66 patients completed more than 2 courses of chemotherapy. The total effective rate (CR + PR) was 39.4% (26/66), including 32 cases in group A and 15 cases effective. There were 34 cases in group B and 11 cases were effective. There was no significant difference between the two groups by X ~ 2 test. Toxicity to bone marrow suppression of leukopenia is the most common, A group Ⅲ ~ Ⅳ grade 19 cases, were using granulocyte-colony stimulating factor (G-GSF) treatment. B group Ⅲ ~ Ⅳ grade 9 cases, 5 cases treated with G-CSF. A handful of anemia and thrombocytopenia. Gastrointestinal reactions mostly grade I ~ nausea and vomiting, abdominal distension and constipation. One patient in each group developed paralytic ileus. Two patients in group A developed severe phlebitis. The median remission and median survival in group A were 6 months and 8 months respectively, while those in group B were 4?