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由氯硝柳胺与1,2-二溴乙烷反应,得到2-(2-溴乙氧基)-5-氯-N-(2-氯-4-硝基苯基)苯甲酰胺,再与乙二醇、二乙二醇、三乙二醇分别反应,得到了三个氯硝柳胺衍生物,其结构由IR1、H NMR和高分辨质谱确证。
Reaction of niclosamide with 1,2-dibromoethane gave 2- (2-bromoethoxy) -5-chloro-N- (2-chloro-4-nitrophenyl) benzamide, Three niclosamide derivatives were obtained by reaction with ethylene glycol, diethylene glycol and triethylene glycol respectively. The structures were confirmed by IR1, H NMR and high resolution mass spectrometry.