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目的 研究肝硬化与肠道菌群的关系。方法 采用大鼠肝硬化模型 ,经益生菌制剂进行预防及治疗的对照研究 ,分别检测血浆内毒素、肝功能指标 ,并对肠道菌群进行培养。结果 预防治疗组和晚期治疗组内毒素水平均低于肝硬化模型组(P <0 .0 5 ) ;肝功能指标治疗组明显好于非治疗组 ;肠道G-需氧杆菌显著少于非治疗组。结论 益生菌制剂对肝硬化大鼠有防治作用。
Objective To study the relationship between liver cirrhosis and intestinal flora. Methods A rat model of liver cirrhosis was established and probiotics were used to prevent and treat the patients. Plasma endotoxin and liver function indexes were detected, and intestinal flora was cultured. Results The levels of endotoxin in the prophylaxis and the late treatment groups were lower than those in the liver cirrhosis model group (P <0.05). The liver function indexes in the treatment group were significantly better than those in the non-treatment group. The G- therapy group. Conclusion Probiotics have preventive and therapeutic effects on cirrhotic rats.