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应用高杂合度微卫星ＤＮＡ多态标志对一个中国人家族性非胰岛素依赖型糖尿病（ＮＩＤＤＭ）家系进行９个致病候选基因连锁分析，观察其可行性及其基因连锁情况。结果显示９个基因分析中，８个得到充分信息量，排除了与本家系ＮＩＤＤＭ的连锁关系。研究表明：（１）应用微卫星多态标志，在个别、较小的家系内可得出连锁结论；（２）本家系的ＮＩＤＤＭ与多数已报道的与ＮＩＤＤＭ有关的基因无连锁关系，表明是由其他基因参与本家系ＮＩＤＤＭ发病；（３）观察家系ＮＩＤＤＭ成员间ＤＮＡ标志的等位基因共有情况可作为家系连锁分析的预筛步骤。
Using high heterozygosity microsatellite DNA polymorphism markers to analyze 9 candidate genes of familial non-insulin dependent diabetes mellitus (NIDDM) in Chinese population, the feasibility and linkage of these genes were observed. The results showed that 8 out of 9 genes obtained sufficient information to exclude the linkage with NIDDM of this family. The results showed that: (1) Using microsatellite polymorphism markers, we could conclude the linkage in individual and smaller pedigrees; (2) NIDDM in this family had no linkage relationship with most of the reported NIDDM-related genes, indicating that By other genes involved in the incidence of this family NIDDM; (3) observation of family members of NIDDM allele consensus between the DNA markers can be used as a pedigree chain analysis of pre-screening step.