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人患恶性疟时,疟原虫寄生的红细胞(PRBC)在微血管的堆积引起微循环损伤,导致器官机能失调和出现严重的临床后遗症。PRBC堆积多发生在脑、心、肺和小肠粘膜下等处,但较少见于淋巴结。脑型疟时PRBC堆积在脑部的发生率比在其他器官的为高,占疟疾死亡例数的55％,约有20％—50％累及中枢神经系统。对19例缅甸脑型疟病人研究发现,环状出血占47％,大脑水肿占36％,所有病人均有微血管阻塞。另外尸检39例泰国恶性疟死亡病人后认为,脑型疟病人的严重性取决于PRBC的堆积,特别是在脑部堆积的程度。
Plasmodium parasitic erythrocytes (PRBCs) accumulate in the microvessels causing microcirculation damage when people develop falciparum malaria, resulting in organ dysfunction and severe clinical sequelae. PRBC accumulation occurred in the brain, heart, lung and small intestine, etc., but less common in lymph nodes. The incidence of PRBC accumulation in the brain during cerebral malaria is higher than in other organs, accounting for 55% of malaria deaths and about 20% -50% affecting the central nervous system. The study of 19 cases of cerebral malaria in Myanmar found that the annular bleeding accounted for 47%, cerebral edema accounted for 36%, all patients have microvascular obstruction. In addition, an autopsy of 39 Thai patients died of falciparum malaria believes that the severity of cerebral malaria depends on the accumulation of PRBC, especially in the brain accumulation.