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异烟肼(INH)是氧化、去甲基化代谢抑制剂,也抑制依赖微粒体径路的细胞色素P_(450),乙酰化作用是INH定量代谢最重要途径,因此,凡具有共同表型的乙酰化药物在选用时。应考虑其药物相互作用。INT也是单胺和双胺氧化酶抑制剂。由其能改变吸收,所以也可能是某些药物的酶诱导物,从而使INH与其它药物之间产生相互作用。【苯妥英】Murray发现癫痫病人用苯妥英(Diphenylhydantoin,DPH)和苯巴比妥各0.1～0.4g又同时服用INH5mg/kg/d,其中11%的病人出现副作用。服用INH出现过分镇静和运动失调者为11%,而服用安慰剂作对
Isoniazid (INH), an inhibitor of oxidation and demethylation, also inhibits cytochrome P_ (450), which is dependent on microsomal pathways. Acetylation is the most important pathway for INH quantitative metabolism. Therefore, INH, which has a common phenotype Acetylated drugs at the time of selection. Should consider its drug interactions. INT is also a monoamine and diamine oxidase inhibitor. It can change the absorption, it may also be some drug inducer, so that INH and other drugs have an interaction between. 【Phenytoin】 Murray found that epilepsy patients with 0.1 ~ 0.4g of diphenylhydantoin (DPH) and phenobarbital with INH5mg / kg / d, 11% of patients with side effects. Take INH appear excessive sedation and motor disorders were 11%, while taking placebo against