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用ＥＬＩＳＡ方法对７０例各型病毒性肝炎血清肿瘤坏死因子（ＴＮＦ）水平检测分析，结果显示各型病毒性肝炎及肝硬化患者ＴＮＦ水平均较正常对照组明显升高（Ｐ＜０．０１）。尤以重症肝炎ＴＮＦ值升高显著，与其它各组比较差异有显著意义（Ｐ＜０．０１）。指出ＴＮＦ水平高低与肝炎活动明显相关，并与病情轻重程度相平行，ＴＮＦ指标可作为肝实质损害轻重的一项检测指标。
The levels of serum tumor necrosis factor (TNF) in 70 patients with various types of viral hepatitis were detected by ELISA. The results showed that the levels of TNF in patients with various types of viral hepatitis and cirrhosis were significantly higher than those in normal controls (P <0.01) . In particular, TNF in severe hepatitis increased significantly, compared with the other groups, the difference was significant (P <0.01). It is pointed out that the level of TNF is significantly correlated with the activity of hepatitis and parallels with the severity of the disease. The TNF index can be used as a detection index for the severity of liver parenchyma.