论文部分内容阅读
目的探讨高强度聚焦超声(high intensity focused ultrasound,HIFU)联合促性腺释放激素激动剂(gonadotropin releasing hormone agonist,GnRH-a)治疗子宫腺肌病剂量学研究。方法选择在同济大学附属第一妇幼保健院接受治疗的子宫腺肌病患者66例,随机分为A、B、C三组,分别应用HIFU、HIFU术前1~2针GnRH-a预处理、HIFU术前3针GnRH-a预处理,评价病灶情况,记录HIFU辐照时间及辐照能量,以能效因子(EEF)为评价指标,分析GnRH-a对HIFU治疗子宫腺肌病的所需能量。结果 A组EEF为(37.37±75.09)J/mm~3;B组EEF为(12.95±21.89)J/mm~3,C组EEF为(1.54±0.47)J/mm~3。C组分别与A组、B组比较,差异有统计学意义(P<0.05)。结论 3针GnRH-a预处理能明显降低HIFU治疗子宫腺肌病所需的能量,从而缩短HIFU治疗时间,提高治疗效率,其联合应用具有良好的临床价值。
Objective To investigate the dosimetric study of high intensity focused ultrasound (HIFU) combined with gonadotropin releasing hormone agonist (GnRH-a) in the treatment of adenomyosis. Methods Sixty-six patients with adenomyosis who were treated in the First Affiliated MCH Hospital of Tongji University were randomly divided into three groups: A, B and C, with HIFU and HIFU pre-treatment with 1 or 2 doses of GnRH-a, HIFU preoperative 3-pin GnRH-a pretreatment, evaluation of lesions, recording HIFU irradiation time and irradiation energy, energy efficiency factor (EEF) as the evaluation index, analysis of GnRH-a HIFU treatment of adenomyosis required energy . Results EEF in group A was (37.37 ± 75.09) J / mm ~ 3, that in group B was (12.95 ± 21.89) J / mm ~ 3, and that in group C was (1.54 ± 0.47) J / mm 3. The difference between group C and group A and group B was statistically significant (P <0.05). Conclusions The 3-needle GnRH-a pretreatment can significantly reduce the energy required for HIFU treatment of adenomyosis, thus shortening the HIFU treatment time and improving the treatment efficiency. The combined application has good clinical value.