天麻钩藤饮对肝阳上亢证头痛患者具有镇痛与提高痛阈的作用 ,并在一定剂量范围内呈量效关系。该方镇痛效应的最低起效剂量为 0 0 98g/kg ,临床常用剂量的效量消退半衰期为 0 6 37h ,消除速率常数为 1 0 88,效应维持时间为 3 6 9h ;提高痛阈的最低起效剂量为 0 14 2 g/kg ,其余相应为 0 786h、0 882和 6 0 7h。表明为维持有效血药浓度 ,提高该方镇痛疗效 ,应缩短给药间隔时间 Tianma Gouteng Decoction has analgesic effect and increase pain threshold in patients with liver-yang hyperactivity headache, and shows a dose-effect relationship within a certain dose range. The minimum effective dose of the analgesic effect was 0 0 98 g/kg, the half-life of the commonly used clinical dose elimination was 0 6 37h, the elimination rate constant was 1 0 88, the effect maintenance time was 368 h, and the pain threshold was increased. The lowest dose was 0 14 2 g/kg, and the rest was 0 786h, 0 882 and 607h. Show that in order to maintain effective plasma concentration and improve the side effects of analgesia, the interval between dosing should be shortened