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目的 探讨胰腺癌术后介入化疗的作用。方法 对 1999～ 2 0 0 3年行根治性手术 4 8例和姑息性手术82例胰腺癌病人在术后进行介入化疗 ,观察介入化疗后病人生存率、肿瘤大小的改变、疼痛缓解率和血清肿瘤标志物的变化。结果 胰腺癌介入化疗后血清肿瘤标志物水平显著降低 ,病人疼痛明显缓解 ,肿瘤缓解率为4 1 5 %。根治性切除组 1年、2年、3年生存率为 74 1%、32 3%和 9 8% ;姑息性手术组 1年、2年、3年生存率为5 3 0 %、7 2 %和 1 4 %。结论 术后介入化疗能抑制胰腺癌肿瘤细胞生长 ,有助于延长生存期和改善疾病相关症状 ,是胰腺癌手术后有效的辅助治疗手段。
Objective To investigate the effect of postoperative interventional chemotherapy on pancreatic cancer. Methods 48 cases of radical surgery and 82 cases of pancreatic cancer undergoing palliative surgery were performed postoperative interventional chemotherapy between 1999 and 2003. The survival rate, tumor size, pain relief rate and serum Changes in tumor markers. Results Serum levels of tumor markers were significantly decreased after interventional chemotherapy in patients with pancreatic cancer. The pain of patients was significantly relieved, and the rate of tumor remission was 41.5%. The 1-year, 2-year and 3-year survival rates of the radical resection group were 74 1%, 32 3% and 98% respectively. The 1-year, 2-year and 3-year survival rates of the palliative surgery group were 53.0% and 72.2% And 14%. Conclusions Interventional chemotherapy can inhibit the growth of pancreatic cancer cells, prolong survival and improve disease-related symptoms. It is an effective adjuvant therapy after pancreatic cancer surgery.