免疫学近20年来的研究强调了Toll样受体在识别病原微生物、激活天然免疫应答从而抗击感染方面的重要角色。当特异的配体结合Toll样受体,细胞使用特异的接头蛋白组织胞内信号转导通路,最终激活转录因子激酶,活化转录因子。看来Toll样受体使用特异的接头蛋白来规范胞内信号流。 Immunology Nearly two decades of research have highlighted the important role of Toll-like receptors in identifying pathogenic microorganisms and activating the innate immune response to fight infections. When a specific ligand binds to a Toll-like receptor, the cell uses a specific adapter protein intracellular signal transduction pathway that ultimately activates transcription factor kinases that activate the transcription factor. It appears that Toll-like receptors use specific adapter proteins to regulate intracellular signal flow.