肥胖是多代谢紊乱综合征的基础 ,是动脉硬化 (AS)发病的危险因素。胰岛素虽然缓解高血糖及高脂血症 ,但却促进脂肪合成。因此 ,控制高血糖与高血脂的有效途径应是促进能量消耗。解偶联蛋白的研究为肥胖的发病机理及治疗提供了新的线索。研究表明 ,遗传或环境因素引起的解偶联蛋白表达降低及其调节因素的紊乱是导致肥胖的原因。纠正这些调节因素的紊乱是治疗多代谢紊乱综合征的关键。 Obesity is the basis of multi-metabolic disorders and is a risk factor for the pathogenesis of atherosclerosis (AS). Although insulin relieves hyperglycemia and hyperlipidemia, it promotes fat synthesis. Therefore, an effective way to control hyperglycemia and hyperlipidemia should be to promote energy expenditure. The research of uncoupling protein provides new clues for the pathogenesis and treatment of obesity. Studies have shown that genetic and environmental factors caused by the decrease of uncoupling protein expression and regulation of its disorder is the leading cause of obesity. Correcting these disorders is the key to treating multiple metabolic disorders.