肺癌一旦确诊 ,70 %已届中晚期 ,但是目前没有理想的和肺癌发展进程一致的模型 ,尤其是晚期肿瘤模型。传统的方法是将肿瘤移植到动物皮下或采用导管移植到支气管内 ,但是不能很好地模拟晚期临床特征 ,如呼吸困难、胸水等。我们采用Ｃ5 7ＢＬ纯系小鼠Ｌｅｗｉｓ肺癌细胞胸腔内注 Once the diagnosis of lung cancer, 70% has advanced in the late, but there is no ideal model consistent with the progress of lung cancer, especially advanced tumor model. Traditionally, tumors have been transplanted subcutaneously into the animal or transplanted into the bronchus using a catheter, but they do not adequately model advanced clinical features such as dyspnea, pleural effusion and the like. We used intracapsular injection of C5 7BL pure mouse Lewis lung carcinoma cells