论文部分内容阅读
用消炎痛(30mg/kg)致急性胃粘膜损害观察胃粘膜钙及胃组织cAMP含量的变化以及异搏定对消炎痛引起的胃粘膜钙及胃组织cAMP含量变化的影响。结果表明:大鼠给予消炎痛后,随着时间延长,胃粘膜损害密度逐步增加.同时胃粘膜钙含量和胃组织cAMP含量逐步降低。预先给予异搏定(5mg/kg,10mg/kg)可使消失痛引起的急性胃粘膜损害明显减轻,同时,胃粘膜钙及胃组织cAMP含量不再下降,cAMP反而有所升高。
The changes of gastric mucosal calcium and gastric cAMP content were observed with indomethacin (30mg/kg)-induced acute gastric mucosal damage, and the effect of verapamil on the changes of gastric mucosal calcium and gastric cAMP content caused by indomethacin. The results showed that after administration of indomethacin in rats, the lesion density of gastric mucosa gradually increased with time, and the calcium content of gastric mucosa and cAMP content in gastric tissue gradually decreased. Pretreatment with verapamil (5 mg/kg, 10 mg/kg) significantly reduced acute gastric mucosal lesions caused by disappearance of pain. At the same time, calcium acetate in the gastric mucosa and cAMP content in the stomach tissue no longer decreased, but cAMP increased instead.