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目的探讨二甲双胍联合阿卡波糖在新发2型糖尿病合并高脂血症患者中的治疗效果及对血脂水平的影响。方法 78例初治2型糖尿病合并高脂血症患者为研究对象,采用信封分组法将患者分为联合组和常规组,每组39例。常规组采用二甲双胍治疗,联合组在常规组基础上联合阿卡波糖治疗。两组患者连续治疗3个月,比较两组患者的疗效及治疗前后的血脂水平。结果联合组患者治疗总有效率94.87%显著高于常规组74.36%,差异具有统计学意义(P<0.05)。治疗前两组患者总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平比较差异均无统计学意义(P>0.05);治疗后联合组患者TC、TG、LDL-C水平低于常规组,HDL-C水平高于常规组,差异均具有统计学意义(P<0.05)。结论二甲双胍联合阿卡波糖在新发2型糖尿病合并高脂血症患者治疗中可提高其临床疗效,改善患者血脂水平,相对单纯使用二甲双胍治疗具有更为显著的疗效。
Objective To investigate the therapeutic effect of metformin combined with acarbose in newly diagnosed type 2 diabetes mellitus patients with hyperlipidemia and its effect on serum lipids. Methods 78 patients with newly diagnosed type 2 diabetes mellitus and hyperlipidemia were enrolled. Envelope grouping method was used to divide the patients into the combined group and the conventional group, with 39 cases in each group. The conventional group was treated with metformin, and the combined group was treated with acarbose on the basis of the conventional group. Two groups of patients for 3 months of continuous treatment, the efficacy of two groups were compared and before and after treatment of blood lipid levels. Results The total effective rate of the treatment group was 94.87%, which was significantly higher than that of the conventional group (74.36%), the difference was statistically significant (P <0.05). The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in the two groups before treatment were not significantly different (P> 0.05). After treatment, the levels of TC, TG and LDL-C in the combined group were lower than those in the conventional group, and the levels of HDL-C were higher than those in the conventional group (P <0.05). Conclusion Metformin combined with acarbose in patients with newly diagnosed type 2 diabetes mellitus and hyperlipidemia may improve its clinical curative effect and improve the level of blood lipids in patients with newly diagnosed type 2 diabetes mellitus, which has more significant curative effect than metformin alone.