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糖尿病发病率逐年上升,糖尿病与动脉粥样硬化关系密切,糖尿病动脉粥样硬化的发病机制十分复杂,研究证实基质金属蛋白酶9与氧化低密度脂蛋白与糖尿病动脉粥样硬化关系密切。高血糖状态下,基质金属蛋白酶9与氧化低密度脂蛋白水平增加,是糖尿病动脉粥样硬化的主要原因,应用药物干预可降低其水平,逆转其对组织的损伤,阻止或者延缓糖尿病动脉粥样硬化的发生、发展,彩色多普勒超声可发现糖尿病动脉粥样硬化早期病变。本文就基质金属蛋白酶9与氧化低密度脂蛋白与动脉硬化的关系及吡格列酮降糖外的抗动脉硬化作用及彩色多普勒早期检测动脉粥样硬化病变进行综述。
The incidence of diabetes increased year by year, diabetes and atherosclerosis are closely related to the pathogenesis of atherosclerosis in diabetes is very complex, studies have confirmed that matrix metalloproteinase 9 and oxidized low-density lipoprotein and diabetes atherosclerosis are closely related. Hyperglycemia, MMP-9 and oxidized low-density lipoprotein levels increased, is the main cause of diabetic atherosclerosis, the application of drug intervention can reduce its level, reverse its damage to the tissue, prevent or delay the development of atherosclerosis Occurrence and development of sclerosis, color Doppler ultrasound can be found in diabetic atherosclerosis early lesions. This article reviews the relationship between matrix metalloproteinase 9, oxidized low density lipoprotein and arteriosclerosis and the anti-atherogenic activity of pioglitazone in addition to the hypoglycemic effect and the early detection of atherosclerotic lesions by color Doppler imaging.