H1受体拮抗剂能与组胺竞争效应细胞上的的组胺H1受体,使组胺不能同H1受体结合,从而抑制其引起过敏反应的作用。近年来,组胺H1受体拮抗剂引起的不良反应已有报道,主要为中枢神经抑制作用,体重增加、心律失常、肝肾毒性等。本文就其不良反应及合理应用作一概述,旨在为临床安全用药提供参考。 H1 receptor antagonists compete with histamine for histamine H1 receptors on effector cells, preventing histamine from binding to H1 receptors and thereby inhibiting their anaphylactic effects. In recent years, histamine H1 receptor antagonist adverse reactions have been reported, mainly for central nervous system depression, weight gain, arrhythmia, liver and kidney toxicity. In this paper, an overview of its adverse reactions and rational use, designed to provide a reference for clinical safety medication.