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目的 :观察妊娠高血压综合征 (妊高征 ,PIH)病人与正常孕妇心率变异性 (HRV)变化 ,以探讨两种状态下交感神经和副交感神经活动、交感神经与副交感神经张力平衡的情况及机理。方法 :2 1例正常孕妇为对照组 (CON组 )。 5 5例妊高征患者分为PIH1组 (轻度妊高征 ) 2 1例 ,PIH2 组 (中度妊高征 ) 19例 ,PIH3 组 (重度妊高征 ) 15例。观察全天HRV变化。结果 :与对照组比较 ,PIH1组、PIH2 组和PIH3 组的LF/HF皆升高 (2 .2 1±0 6 5 ,2 .33± 0 .78,4 .5± 1.2 1vs 1.78± 0 .70 ) ,差异有显著意义 (P <0 .0 5或P <0 .0 1)。PIH3 组的HF降低(131.0 3± 6 1.5 9vs 2 4 5 .6 1± 12 1.0 3)ms2 ,LF升高 (5 2 6 .77± 10 7.32vs 389.4 0± 16 6 .5 1)ms2 ,差异有显著意义 (P<0 .0 5 )。PIH1组、PIH2 组HF和LF与对照组无差异。结论 :妊娠高血压综合征患者存在交感神经和副交感神经平衡紊乱 ,重度妊高征病人交感神经活动显著增强 ,而副交感活动明显减弱
Objective: To observe the changes of heart rate variability (HRV) in patients with gestational hypertension (PIH) and normal pregnant women in order to investigate the balance between sympathetic and parasympathetic nerve activities, sympathetic and parasympathetic tone under the two conditions and mechanism. Methods: Twenty-one normal pregnant women were control group (CON group). Fifty-five PIH patients were divided into PIH1 group (mild PIH) 21 cases, PIH2 group (moderate PIH) 19 cases and PIH3 group (severe PIH) 15 cases. Observed changes in HRV throughout the day. Results: Compared with the control group, the LF / HF of PIH1, PIH2 and PIH3 groups were both increased (2.21 ± 0.65, 2.33 ± 0.78, 4.15 ± 1.2 1 vs 1.78 ± 0). 70), the difference was significant (P <0.05 or P <0.01). HF in the PIH3 group decreased (131.0 3 ± 6 1.5 9 vs 24.5.61 ± 12 1.0 3) ms2 and LF increased (52.677 ± 10 7.32 vs 389.4 0 ± 16 6 .5 1) ms2 Significant (P <0.05). PIH1 group, PIH2 group HF and LF and the control group no difference. CONCLUSIONS: Sympathetic and parasympathetic balance disorders occur in patients with pregnancy-induced hypertension syndrome, and sympathetic activity is significantly increased in patients with severe PIH but significantly decreased in parasympathetic activity