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目的:评价斑蝥酸钠维生素B_6注射液联合化疗治疗晚期非小细胞肺癌的临床疗效及不良反应。方法:将68例晚期非小细胞肺癌患者随机分为两组,治疗组(35例)给予斑蝥酸钠维生素B_6注射液25 ml,同时进行多西紫杉醇联合奈达铂化疗,对照组(33例)予单纯联合化疗。治疗2周期后评价两组的疗效、毒副反应及生活质量改变。结果:治疗组、对照组的有效率分别为54.29%和24.27%(P<0.05)。治疗组患者生活质量提高率高于对照组(P<0.05),毒性反应小于对照组(P<0.05)。结论:斑蝥酸钠维生素B_6注射液联合化疗治疗晚期非小细胞肺癌可提高临床疗效,改善患者的生活质量,同时可减少化疗毒副反应。
Objective: To evaluate the clinical efficacy and adverse reactions of sodium cantharidinate and vitamin B_6 injection combined with chemotherapy in the treatment of advanced non-small cell lung cancer. Methods: Sixty-eight patients with advanced non-small cell lung cancer were randomly divided into two groups. The treatment group (n = 35) was given 25 ml sodium cantharidin vitamin B 6 injection, and docetaxel combined with nedaplatin chemotherapy. The control group (n = 33) ) To simple combination chemotherapy. After 2 cycles of treatment, the curative effect, side effects and quality of life of the two groups were evaluated. Results: The effective rates of treatment group and control group were 54.29% and 24.27% respectively (P <0.05). The improvement rate of quality of life in the treatment group was higher than that of the control group (P <0.05), and the toxicity was less than that of the control group (P <0.05). Conclusion: Sodium cantharidin and vitamin B_6 injection in combination with chemotherapy in the treatment of advanced non-small cell lung cancer can improve the clinical curative effect, improve the quality of life of patients and reduce the side effects of chemotherapy.